The Best Nootropics For Depressionbest nootropic depression

Nootropics are receiving some great attention for their ability to improve mental clarity, cognition, and focus. Even though the basic definition of a nootropic is a “compound that improves cognitive abilities,” they can also be used for other mental health purposes such as aiding with depression or anxiety. Because nootropics can also help with motivation, executive function, and mental well-being, they are often used to improve symptoms of depression. While they are not prescribed antidepressants, using nootropics for depression can help with clinical depression without the common side effects of prescription drugs used to treat depression.

They are safe when used as directed, and they can be taken temporarily for a brief uplift in mood, or they can be taken for long-term assistance. If you are wanting to find the best nootropic for depression, this guide can help find the right one for you.


Piracetam was one of the first nootropics developed, and it is best known for improving memory and cognitive focus. However, more studies are showing that it is one of the best nootropics for depression because it is long-lasting throughout the day, safe, and has so many benefits to the brain overall.

It increases oxygen and blood flow to the brain, which gives people more energy and battles the chronic fatigue that goes with depression. Piracetam can also increase dopamine in the brain, creating more feelings of happiness.

Piracetam has been in use for over 40 years, and it is known to be both safe and effective. For people just starting to explore nootropics, Piracetam is often recommended because it is mild, yet has a long duration. It’s safe for long-term use where the benefits can increase when taken for long periods.

It’s important to take Piracetam with food to aid in absorption and to stay hydrated to prevent headaches, which is the most common side reported side effect. Headaches can also be avoided when taken with a choline supplement such as Citicoline.

Aniracetam and Phenylpiracetam

Part of the -racetam group of chemical compounds, Aniracetam and Phenylpiracetam are very similar to Piracetam. Both were developed not long after Piracetam, and Aniracetam was originally created to be somewhat stronger. It does a great job of improving focus and energy, helping people with depression combat the fatigue that often accompanies depression. However, it also benefits perception and visual acuity, which can help lift some of the mental fog that people suffering from depression experience.

Phenylpiracetam is about ten times stronger than Piracetam and also much stronger than Aniracetam. It is effective within about 30 minutes and lasts up to five hours. It offers similar benefits to Aniracetam and Piracetam, though much stronger. This is the nootropic to go with if you are seeking a more pronounced lift in mental energy and focus.

For people who have tried Piracetam and want something a bit stronger, Aniracetam or Phenylpiracetam may be the best nootropics for depression. It is safe, and Aniracetam is fine for daily, long-term usage. Because of its strength, Phenylpiracetam is safe to use every other day for two weeks at a time, while taking one week off to avoid building up a tolerance to it. As with any -racetam nootropic, taking with food will help absorption, and taking a choline supplement and staying hydrated will prevent headaches.


Tianeptine is one of the more potent nootropics that is most often used to treat clinical depression. Known as a tricyclic antidepressant, due to its chemical structure being made of three rings of atoms, Tianeptine works as an alternative to SSRIs and other prescription antidepressants.

Studies show that Tianeptine is very effective against clinical depression, severe depressive episodes, and post-traumatic stress disorder. It also has anxiolytic effects, meaning it can calm anxiety and panic disorder, which often accompany depression. Tianeptine can also improve cognitive function, so people who take it will often find a decrease in depression and an increase in mental clarity and wellbeing.

Unlike many prescription antidepressants, Tianeptine has a very low occurrence of side effects. While it works within 60 minutes to improve symptoms of depression, when taken over consistently over several weeks, long-term improvement in mental health and wellness is often observed.


Noopept has a lot of similarities to Aniracetam, though it is much more potent, and it acts more quickly, with many people reporting feeling its effects within 30 minutes of taking it. Noopept is one of the best nootropics for depression because it greatly improves motivation and productivity, which many people suffering from depression struggle with. This powerful nootropic also supports neuron health in the brain and can even heal damaged neurons, which also leads to an improvement in mood and mental wellbeing.

Noopept is very strong and fast-acting, and that also means its effects don’t last for long periods – generally just a few hours. Many people prefer to take small amounts throughout the day for extended, sustained benefits. There are few side effects reported with it, and it’s safe for long- term use, making this a great option for people wanting to try a nootropic to battle depression.



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