Sulbutiamine Dosage, Usage, Benefits & Reviews

Sulbutiamine is a synthetic derivative of thiamine (vitamin B1) that is used to treat different forms of asthenia (medical term for weakness), chronic fatigue and other similar pathologies. Thiamine is a very important vitamin for optimal cognitive functions. For example, thiamine deficiency is associated with memory dysfunction, cognitive disorders and changes in cellular metabolism.

Due to its effects on metabolism, thiamine is often found as an ingredient in fat-loss and energy boosting nutritional supplements. However, thiamine does not have a good lipophilicity (fat-solubility) profile. This prevents it from crossing the blood-brain barrier.

Therefore, scientists synthesised Sulbutiamine, which has two thiamine molecules bound together. This chemical structure improves its bioavailability and allows Sulbutiamine to cross the blood-brain barrier more readily than thiamine.

“Consequently, Sulbutiamine can effectively elicit its neuromodulatory properties.”

These include memory improvement as demonstrated in mice studies as well as enhancement of cognitive functions. Furthermore, Sulbutiamine is used by patients with Alzheimer’s disease.

Once ingested, Sulbutiamine is absorbed by the intestines, the blood system then transports it to the central nervous system (CNS). Sulbutiamine effects on the CNS have been widely studied. For example, Sulbutiamine stimulates the reticular activating system (RAS), which is responsible for arousal and motivation.

As mentioned before, Sulbutiamine easily crosses the blood-brain barrier. Evidence shows that Sulbutiamine increases the levels of thiamine and thiamine phosphate esters in the brain more effectively than thiamine itself. Due to this reason Sulbutiamine, a synthetic derivative, is considered to be a more enhanced version of thiamine.

Sulbutiamine also has glutamatergic and dopaminergic effects, mainly in the hippocampus and prefrontal lobe areas of the brain.

Sulbutiamine influences dopamine neurotransmitter, which is responsible for our learning abilities, focus, rewards and pleasure.

“This compound therefore helps people with symptoms of asthenia, depression and even behavioural disorders.”

Benefits of Sulbutiamine:

Sulbutiamine is among the most popular nootropics on the market today. It provides a whole range of benefits, including improved memory, cognition and mood. A list of benefits is presented below.

Mood improvement. By influencing dopamine neurotransmitter, which controls our reward and pleasure centres, Sulbutiamine acts as a very powerful anti-depressant. It has been successfully used by people suffering from depression, anxiety or shyness. It must be noted that these benefits are temporary and tend to decline with continued use. It is why healthcare professionals do not suggest Sulbutiamine as the essential treatment for such mood disorders.

Memory improvement. It is understood that by boosting the transmission of glutamate, dopamine and acetylcholine, this compound can improve memory. This has been demonstrated in patients who suffer from Schizophrenia and Alzh

eimer’s disease. Decision making, planning, alertness, general reflexes and energy level are also positively influenced by Sulbutiamine.

Treatment of asthenia. Different studies have concluded that Sulbutiamine may be an effective substance to treat asthenia. However, more research is still required in this area.

Erectile dysfunction. Sulbutiamine is also studied as a treatment for erectile dysfunction. In fact, there are some promising results as a number of users reported increased arousal and ability to achieve erection following Sulbutiamine use.

Other uses. Mood, memory, me

ntal energy and certain health improvements are quite well known among the users of Sulbutiamine. It has a few other, off-label, benefits. Feelings of pleasure and euphoria are reported, as well as relieved anxiety and stress. Gym-goers use Sulbutiamine to burn fat and suppress hunger.

Recommended dosage:

The recommended daily dosage is between 200-400 mg. Therefore, if you never used this nootropic start with 200 mg and see if it affects you. Some users report no effects following this dosage. Therefore, if you are one of them, you should increase the dosage to 400 mg/day.

Side effects of Sulbutiamine:

If taken at the recommended dosages, Sulbutiamine has very few reported side effects. Even though Sulbutiamine is well tolerated, it is easy to develop a tolerance. In order to avoid tolerance and decreasing effects, it is recommended to take breaks in usage. Most other side effects are to do with being irritable, but this is often caused by going over the recommended dosage. Therefore, if you experience irritability, anxiety, headache, nausea or skin rashes, you should discontinue the use of Sulbutiamine. Sulbutiamine does not have psychostimulant properties.


  • Improves mood and memory
  • Increased brain oxygen and glucose
  • Reduces mental fatigue and tiredness

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In summary, Sulbutiamine is an effective nootropic to increase mental energy and give a boost to the overall brain activity. In addition, it provides a number of other positive benefits.