Oxiracetam vs PramiracetamOxiracetam and Pramiracetam are two of the lesser known supplements. While both of them have off-label and clinical use; many users begin with either Aniracetam or Piracetam as their first cognitive supplements. But once you are able to experience the effects of these compounds, you will become interested in trying out of the more potent racetams.

A wide range of benefits concerning intellect and cognition have been reported following Pramiracetam and Oxiracetam use. While both substances act very similarly, there are also many key differences between the two. Thus, the aim of this article is to present the information on their benefits, mechanisms and offer suggestions on which one is the best for you.

Oxiracetam and its benefits:

Oxiracetam is one of Piracetam’s more powerful analogs with a greater effect on studying. Experts have concluded that Oxiracetam improves memory, learning and cognition. The supplement specifically increases hippocampally-mediated learning which subsequently enhances the creation of a long-term memory. Another benefit associated with Oxiracetam use is an increase in speed of memory retrieval.

Many reviews have also suggested that the Nootropic makes it easier to comprehend perplexing ideas that you have encountered for the first time. Hence it has a good reputation for being ideal for individuals in engineering and math disciplines. Additional benefits that Oxiracetam brings are increased productivity and concentration.

“An improvement in attention span occurs with the use of this supplement and you will find that you can have a more deep focus without other distracting thoughts coming into your head.”

A heightened sense of energy, alertness, and mental sharpness have led many people to falsely believe that they are taking a stimulant that affects only the Central Nervous System, but this is not the case. A higher sense of motivation is also noted to come from Oxiracetam. If you desire to feel a real “working effect” Oxiracetam is not the best Nootropic for you.

However, Oxiracetam is known to improve one’s performances during tests. One difference that you will feel while taking this supplement is a heightened sensory perception (i.e. sight and hearing). For example, users state that they are able to see more detail in colors and the surrounding world.

Pramiracetam and its benefits:

Pramiracetam is one of the strongest Nootropics with Phenylpiracetam being the only supplement that rivals its potency. However, users report that they feel the effects of Pramiracetam more deeply. For example, Piracetam has been known to take 1-2 weeks before the full benefits actually materialize, but while taking Pramiracetam, the effects occur literally minutes after taking it.

Although many of the effects are similar to other racetams, using Pramiracetam is comparable to turning the volume up on each benefit. It also affects the fluid intelligence which is closely associated with your working memory.

“Pramiracetam is famous for improving learning capacity and memory by increasing synaptic plasticity.”

In addition, an improvement of general cognitive functions is seen, and there have been many reports suggesting that the supplement provides greater focus and concentration. This allows its users to become better at information processing and problem solving. One of the most commonly reported experiences while taking Pramiracetam is the sense of being engrossed with intense drive on a single task.

An increase in verbal processing is also evident, making it easier during tasks, such as holding conversations. Although Pramiracetam and Oxiracetam are both great in an academic setting, they are used in clinical settings too. For example, treatment for Alzheimer’s disease is one of the most significant ones right now.


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Method of Action comparison:

Oxiracetam works by modifying several important neurotransmitters in the brain. Two main neurotransmitters are: glutamate and acetylcholine. Both of them are closely associated with many key cognitive processes, including learning and memory.

With the presence of Oxiracetam, both chemicals are made more efficiently because it attaches itself to their receptor sites and inhibits them from becoming inactive.

Oxiracetam vs Pramiracetam 3This is very effective at increasing the communication between neurons. Improved communication between neurons alongside increased stimulation of receptors lead to the creation of new synapses. Consequently, there is a greater formation of memory.

Pramiracetam and Oxiracetam work very similarly but do have a number of distinctions. Firstly, Pramiracetam is fat soluble so it is essential that is absorbed by either taking it on a full stomach or with milk. Since it is not water soluble like Piracetam and Oxiracetam, it has the ability to be absorbed faster and make its way to the brain, reaching a maximum blood level concentration within about half an hour.

It has been demonstrated that Pramiracetam is about 30 times more potent that Piracetam which would make it five time more potent that Oxiracetam.

Pramiracetam vs. Oxiracetam: Which is better?

When it comes down to comparing the two supplements it is obvious that Pramiracetam is the strongest of the pair. It provides more boost to the brain along with noticeable effects on mental energy. However, this is not the only thing that matters. In some cases Oxiracetam might actually be a better option.

For example, Pramiracetam is a supplement that many want to take only on a special occasion while Oxiracetam is better for daily use. In terms of tolerance development, evidence suggests that it does only happen with Oxiracetam but not Pramiracetam.

It is advised that you start with Oxiracetam and once you are more knowledgeable about the effects of this Nootropic you move to Pramiracetam. Lastly, try to give each supplement a fair chance to work before you decide, because sometimes it takes about a week or two for it to start working fully.