Nefiracetam Dosage, Usage & Benefits

Nefiracetam is a nootropic compound, which due to structural similarities is often compared to Aniracetam, but has a higher potency. If you have experienced benefits from using supplements, such as Piracetam or Aniracetam, you will definitely be interested in trying this cognitive enhancer out. In terms of its chemical structure, Nefiracetam and Aniracetam are very similar, but the way they behave and work are slightly different.

Nefiracetam activates the cholinergic, GABAergic and monoamigernic systems. In addition, Nefiracetam helps open calcium channels in the activated neurons which subsequently amplifies the message sent by the neurotransmitters. Calcium influx is important for the long-term potentiation (LTP).

LTP is the process by which signal transmission between the two simultaneously active neurons is strengthened. LTP is demonstrated in the hippocampus, an area of the brain that is especially important in the formation and retrieval of memory. In addition, Nefiracetam provides neuroprotective benefits.

Like Aniracetam this nootropic is fat soluble, and this allows it to cross the blood-brain barrier and enter the central nervous system with ease. Reviews of Nefiracetam show that it has a wider range of effects than other nootropics, such as Piracetam and Aniracetam.


  • Heightened memory and clear thinking
  • Reduced stress, anxiety and depression
  • Enhanced focus, mood and perception

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Benefits of Nefiracetam:

Nefiracetam has been shown to have strong potential in the cases of seizures. Studies indicate that it has very little effect on stopping them from occurring, but it has the ability to reduce the amount and time span of the seizures that may occur. Nefiracetam also has the ability to induce benefits that are typical to the nootropic family.

Some of these benefits include an improved memory, learning capacity, and spatial learning. There is also evidence to show that it aids individuals suffering from depression.

“In terms of improving one’s attention span, focus, and concentration, Nefiracetam is one of the best Nootropics.”

Another benefit of Nefiracetam is that it is able to protect the neurons in the brain. It may also help in reversing the brain damage. Therefore, Nefiracetam could provide major benefits to people who use certain drugs or suffer from rapid aging.

Typical Nefiracetam dosage:

Recently, there have been multiple studies that have recommended different dosages of Nefiracetam. One study recommended a range from 8.72 mg per kg of body weight to 29.07 mg/kg. However, this level of dosage is meant for someone suffering from severe depression or seizures.

A more accepted and advised dosage level ranges from 5 to 16 mg/kg which is between 330-1100 mg for a person that weighs 150 pounds. If purchased not in a powder form, Nefiracetam is also available in 500 mg tablets.

The above doses should be split into two or three equal administrations throughout the day. Following a 30 to 60 minute span after oral ingestion the supplement acts fast and reaches the brain. As is fairy similar across the board of nootropics, it will take multiple days or weeks of dosages before the full effects are actually experienced.

Side Effects:

Nefiracetam’s side effects are very comparable to those of other racetams. They include irritability, headaches, fatigue, stomach ailments and nausea. Most cases, however, are not serious and pass very quickly. To overcome the headaches you can add a Choline supplement such as Alpha GPC. Unless used in excessively high doses you should not experience any other side effects.

All studies on the side effects of Nefiracetam have all been conducted on animals with observed toxicity risk. Although no upper limit has been determined currently, dosages up to 900 mg have been seen to be non-toxic.