Coluracetam is a relatively new compound in the racetam family which has the potential to take the market of brain supplements by storm in the coming years. Similar to other popular nootropics Coluracetam derives from Piracetam. The Mitsubishi Tanabe Pharmaceutical Corporation invented it in Japan and had it registered in 2005.
The patent was then transferred to another company which is now held accountable to conduct testing and they are called BrainCells Inc. Phase 2A trials of Coluracetam were complete and the company suggested that Coluracetam shows potential for treating ailments such as Major Depressive Disorder (MDD) and other anxiety problems.
While there has been a lot of interest expressed by the medical community on the matter of cognitive enhancement substances, users of nootropics are also waiting to find out how this supplement will work for them.
How does Coluracetam work:
The structure and mechanisms of action of Coluracetam are reported to be different compared to other racetams (e.g. Piracetam and Aniracetam). Coluracetam is a choline-uptake enhancer as it regulates the rate-limiting process whereby choline is drawn into a neuron in order to be converted into the neurotransmitter Acetylcholine.
“Coluracetam facilitates the synthesis, release and availability of Acetylcholine which is a very important neurotransmitter involved in a number of cognitive processes, such as memory formation, learning and focus.”
Coluracetam may be adopted by medical practitioners as a supplement for preventing injuries concerning the eyes. It has a major effect on improving one’s eyesight and that is where it gets its name from. While its availability is currently limited, thousands of Americans have tested this Nootropic and reported its positive benefits.
Coluracetam enhances Choline uptake in the body. In other words, Coluracetam improves the degree and efficiency by which the body and the brain use Choline. Using Choline is a key process to synthesize a neurotransmitter called Acetylcholine. Acetylcholine is believed to play a very significant part in memory formation, learning capacity, and other mental ability processes.
Acetylcholine also potentiates AMPA receptors in the brain for glutamate. The most central source of synaptic plasticity for all neurotransmitters within the body is glutamate. It has the ability to create new connections in the neurons.
- Heightened memory and clear thinking
- Reduced stress, anxiety and Depression
- Enhanced mood, focus and Perception
Perhaps one of the main benefits from Coluracetam is the long term improvement in individuals whose memories are damaged or impaired. Since there has been very little testing on humans so far, most evidence comes from experiments done on animals.
For example, Coluracetam was administered to rats and after usage their memory was seen to improve even after it had gone through its body, thus suggesting a type of long lasting effect. The supplement is also very effective in treating individuals who suffer from MDD and other general anxiety issues, as shown from the Phase 2A trials.
These effects were shown in patients who had not experienced benefits from using any other anti-depressants. Users of Coluracetam report reduced levels of stress and anxiety.
Due to this supplements rarity, there is currently no medically recommended level of dosage. But most studies have shown that a dosage containing about 200 mg a day would help the everyday person.
It is also obvious that the dosage level may also be dependent upon ones reasoning for taking the supplement in the first place. Take up to 100 mg three times a day if you suffer for the Major Depressive Disorder.
If you have an anxiety disorder, the aforementioned would also be a reasonable dosage. However, if you have never used racetams before, you will come to find that starting with 20 mg a day will be effective. This dosage should then be gradually increased over time.
As stated before, since there is limited data on Coluracetam there is not much information concerning the toxicity levels of this nootropic. However it seems that it is safe given how it works and how it compares to other racetams. It has been indicated by BrainCells Inc. that they have not seen any negative side effects when Coluracetam was used in multiple dosages ranging around 80mg. Using other racetams as our guide, an assumed side effect may be a headache.